abstract：PURPOSE OF REVIEW:Myocardial fibrosis is a common feature of many cardiomyopathies, including hypertrophic cardiomyopathy. Myocardial fibrosis has been shown to be reversible and treatable with timely intervention. Although early detection and assessment of fibrosis is crucial, adequate diagnostics are still in develop...

journal_title：Current opinion in cardiology

authors： Won S,Davies-Venn C,Liu S,Bluemke DA

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of clinically available genetic tests for heritable cardiovascular diseases has recently increased because of novel gene discoveries and advancements in DNA sequencing technologies. The purpose of this review is to provide up-to-date genetic testing information and guidance on how to incorp...

journal_title：Current opinion in cardiology

authors： Sturm AC,Hershberger RE

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertrophic cardiomyopathy (HCM) is the second most common childhood heart muscle disease and is the most common cause of unexpected sudden cardiac death in young people. The purpose of this review is to describe the risk of sudden death, to assess which of the criteria conventionally used as indicat...

journal_title：Current opinion in cardiology

authors： Östman-Smith I,Rossano JW,Shaddy RE

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Frequent media reports of sudden cardiac arrest or death (SCA/SCD) keep alive a debate as to how best to prevent these tragedies. Several new studies in the past 2 years serve as an impetus to reframe the debate into a reasonable discussion that seeks to obtain more evidence wherever needed and to dev...

journal_title：Current opinion in cardiology

authors： Vetter VL,Dugan NP

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to offer an overview of the use of thrombolytic therapy in acute pulmonary embolism. Clinicians including internists, surgeons, pulmonologists, and other specialists continue to face decisions regarding massive and submassive acute pulmonary embolism in their daily routines....

journal_title：Current opinion in cardiology

authors： Tapson VF

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Octogenarians represent the fastest-growing segment of the population. Over 40% manifest cardiovascular disease, frequently in an advanced state requiring surgical revascularization. Increased mortality, morbidity, and expense in this high-risk group, with decreased longevity, present a growing challe...

journal_title：Current opinion in cardiology

authors： Kurlansky P

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The emerging role of stress and particularly exercise echocardiography in mitral regurgitation has been recently emphasized. In fact, the evaluation of mitral regurgitation only under resting conditions might underestimate the full impact of the lesion and its clinical effects. RECENT FINDINGS:Exerci...

journal_title：Current opinion in cardiology

authors： Lancellotti P,Magne J

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyslipidaemias are noted in all stages of chronic kidney disease (CKD). Currently most evidence for their treatment comes from secondary retrospective analyses of patient subgroups with CKD recruited into clinical trials powered of hypertensive and dyslipideamic cohorts powered for cardiovascular endp...

journal_title：Current opinion in cardiology

authors： Jenkins M,Goldsmith D

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Ticagrelor is a new, direct acting, reversibly binding P2Y12 receptor antagonist with more potent inhibition of platelets than clopidogrel and which does not require metabolic activation. It was compared with clopidogrel, on a background of the standard of care in a randomized trial in the Platelet In...

journal_title：Current opinion in cardiology

authors： Held C

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Maximalist low-density lipoprotein (LDL)-lowering strategies such as lowering LDL as much as possible or, alternatively, using the most potent LDL-lowering regimens have become increasingly popular. Almost all attention has focused on the potential advantages of these approaches with little focus on t...

journal_title：Current opinion in cardiology

authors： Sniderman AD,De Graaf J,Couture P

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The presence of tricuspid regurgitation in the setting of right ventricular dysfunction is associated with poor prognosis. The purpose of this review is to describe the pathophysiology of functional tricuspid regurgitation, summarize the current reports favoring a more aggressive approach toward tricu...

journal_title：Current opinion in cardiology

authors： Pinney SP

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Pericardial diseases are relatively common in clinical practice, either as isolated disease or as manifestation of a systemic disorder. The aim of the present study is to review more recent updates on their contemporary management. RECENT FINDINGS:The cause of pericardial diseases is varied according...

journal_title：Current opinion in cardiology

authors： Imazio M

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Treatment options for late-stage biventricular heart failure are limited but include medical therapy with intravenous inotropes, biventricular assist devices (Bi-VADs) and the total artificial heart (TAH). In this manuscript, we review the indications, surgical techniques and outcomes for the TAH. RE...

journal_title：Current opinion in cardiology

authors： Kasirajan V,Tang DG,Katlaps GJ,Shah KB

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the application of next-generation sequencing (NGS) technologies in the identification of the causation of nonsyndromic genetic cardiomyopathies. RECENT FINDINGS:NGS sequencing of the entire genetic coding sequence (the exome) has successfully identified five novel genes and caus...

journal_title：Current opinion in cardiology

authors： Norton N,Li D,Hershberger RE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Transseptal endocardial left-ventricular pacing has a number of potential advantages over left-ventricular epicardial pacing from the coronary sinus, for implantation of cardiac resynchronization therapy (CRT) devices. In this study we review the risks and potential benefits. RECENT FINDINGS:Permanen...

journal_title：Current opinion in cardiology

authors： Whinnett Z,Bordachar P

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate whether long-term antiplatelet therapy may be effective and well tolerated. RECENT FINDINGS:Five important studies assessed the efficacy and safety of clopidogrel therapy in different settings. However, the problems concerning the duration of therapy are based substantially on the Clopido...

journal_title：Current opinion in cardiology

authors： Bolognese L,Angiolillo DJ

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Prolonged sitting (sedentary behavior) has deleterious cardiovascular and metabolic correlates; however, little is known about the associations of too much sitting with all-cause and cardiovascular mortality risk. In addition to the adverse effects of total sitting time, the manner in which it is accu...

journal_title：Current opinion in cardiology

authors： Dunstan DW,Thorp AA,Healy GN

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the recent advances in stress echocardiography, with particular attention to articles published in 2010 and 2011. It summarizes the developments in the diagnostic and prognostic capabilities of stress echocardiography, discusses new data regarding the safety of stress echocardiogr...

journal_title：Current opinion in cardiology

authors： Cullen MW,Pellikka PA

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are widely utilized for low-density lipoprotein lowering and for prevention of atherosclerotic cardiovascular disease. Although these drugs have a good safety record, increased risk of developing diabetes during extended use has recently garnered attention. Here we review clinical trial eviden...

journal_title：Current opinion in cardiology

authors： Sampson UK,Linton MF,Fazio S

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetes is an increasingly prevalent risk factor for coronary and other vascular disease. Recent trials in patients with diabetes have examined the effects of intensive glycemic control on cardiovascular outcomes, and treatment of common concomitant risk factors, in particular hypertension and dyslip...

journal_title：Current opinion in cardiology

authors： Webster MW

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with tetralogy of Fallot are subject to arrhythmic sequelae that substantially impact morbidity and mortality. This review focuses on recent advances in our understanding of the prevalence and types of arrhythmias encountered. Diagnostic and prognostic tools are considered and therapeutic opt...

journal_title：Current opinion in cardiology

authors： Le Gloan L,Khairy P

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:On the very solid background of experimental and clinical studies pointing to the cardiovascular risks associated with depressed vagal reflexes and supported by specific experiments in animal models of heart failure, we are witnessing a rapidly growing interest in the very untraditional approach to th...

journal_title：Current opinion in cardiology

authors： Schwartz PJ

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on high-density lipoprotein (HDL) biology and emerging new HDL-based therapies for athero-thrombosis. RECENT FINDINGS:Atherosclerotic cardiovascular disease remains a major public health threat despite a significant decline over the past three decades. Although current medical th...

journal_title：Current opinion in cardiology

authors： Shah PK

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Health professionals are presented with the challenge of prescribing physical activity that is likely to be sustained by the sedentary majority. Walking is eminently suited to physical activity prescription for inactive individuals as it is accessible to men and women of all ages and social groups and...

journal_title：Current opinion in cardiology

authors： Murtagh EM,Murphy MH,Boone-Heinonen J

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D deficiency is common throughout the world, with a particularly high prevalence in northern latitudes and colder climates. Although the best known sequelae of vitamin D deficiency involve the musculoskeletal system, a growing body of evidence suggests that vitamin D status may influence cardi...

journal_title：Current opinion in cardiology

authors： Swales HH,Wang TJ

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the role of statin therapy in patients with acute coronary syndromes. These drugs modulate endothelial function and stabilize atherosclerotic plaque by inhibiting oxidative stress and inflammation and may provide a relevant clinical benefit in unstable patients. RECENT FINDINGS:...

journal_title：Current opinion in cardiology

authors： Nusca A,Melfi R,Patti G,Di Sciascio G

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this study, we review the evidence for both long-standing and newer oral antiplatelet agents as secondary prevention in coronary artery disease, and give our opinion on where each agent's treatment role lies. RECENT FINDINGS:Platelets play a pathological role in acute coronary syndromes and are th...

journal_title：Current opinion in cardiology

authors： Behan MW,Chew DP,Aylward PE

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Our understanding of the interactions of genes and pathways during heart development continues to expand with our knowledge of the genetic basis of congenital heart disease. Along with the discovery of specific genes that cause lesions, recent research has focused on the interactions of some previousl...

journal_title：Current opinion in cardiology

authors： Wolf M,Basson CT

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The Brugada syndrome has been investigated in depth since its description in 1992 both on a clinical and on a basic research level. Since the discovery of the first genetic defect in 1998, several genes have been subsequently identified. However, to date all these genes together explain only 30% of th...

journal_title：Current opinion in cardiology

authors： Campuzano O,Brugada R,Iglesias A

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Transcatheter aortic-valve implantation is a promising new treatment modality for patients with aortic-valve disease, where it may revolutionize the treatment of elderly and high-risk patients. RECENT FINDINGS:The two devices currently available, the Edwards Sapien valve and the Medtronic CoreValve s...

journal_title：Current opinion in cardiology

authors： Ruel M,Labinaz M

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the electrophysiological profile and the clinical portfolio of dronedarone, a new multichannel-blocking antiarrhythmic drug developed for the treatment of atrial fibrillation. RECENT FINDINGS:Dronedarone is a derivative of amiodarone that is free of iodine and less lipophilic. The drug ha...

journal_title：Current opinion in cardiology

authors： Duray GZ,Ehrlich JR,Hohnloser SH

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article is to provide an overview of investigational work which has demonstrated the ability of MRI to define abnormalities caused by coronary heart disease. There have been numerous recent advances in the MRI assessment of coronary heart disease which warrant review. RECENT FINDI...

journal_title：Current opinion in cardiology

authors： Vick GW 3rd

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Open aortic arch surgery is highly invasive and may result in significant morbidity. Recent innovations in thoracic stent-graft technology have facilitated methods of replacing the aortic arch without deep hypothermic circulatory arrest or even cardiopulmonary bypass. We present a review of the curren...

journal_title：Current opinion in cardiology

authors： Desai ND,Szeto WY

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Coarctation of the aorta is the discrete narrowing of the proximal descending aorta and is the sixth most common lesion in congenital heart disease. Repair of the coarctation can relieve the obstruction, but recurrent coarctation and future aneurysm formation can occur, and a heightened risk of vascul...

journal_title：Current opinion in cardiology

authors： Tanous D,Benson LN,Horlick EM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Carotid endarterectomy (CEA) is still considered the gold standard in the treatment of patients with significant carotid stenosis and has proven its value over the past decades. Endovascular techniques have evolved, and carotid artery stenting (CAS) is challenging CEA to become the better treatment. V...

journal_title：Current opinion in cardiology

authors： Zeebregts CJ,Meerwaldt R,Geelkerken RH

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Since the last few years, three-dimensional echocardiography (3DE) has become an accurate tool for mitral stenosis assessment. We will review the latest developments of 3DE in this matter. RECENT FINDINGS:Accuracy of 3DE planimetry is superior to the accuracy of the invasive Gorlin's method for mitra...

journal_title：Current opinion in cardiology

authors： Zamorano J,de Agustín JA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update of the literature describing the link between lipoprotein a and vascular disease. RECENT FINDINGS:There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis. Several mechanisms may be ...

journal_title：Current opinion in cardiology

authors： Tziomalos K,Athyros VG,Wierzbicki AS,Mikhailidis DP

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:New data have emerged over the last few years about the role of fibrates in treatment of microvascular and macrovascular disease. RECENT FINDINGS:Endpoint studies have been conducted with fibrates in coronary heart disease (CHD) since 1971 and initial results were contradictory. Fibrates later showed benefits ...

journal_title：Current opinion in cardiology

authors： Wierzbicki AS

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Bleeding has recently been identified as a major adverse outcome in patients with acute coronary syndromes. In this review, the importance of the association of bleeding with mortality and strategies to reduce bleeding with percutaneous coronary intervention are discussed. RECENT FINDINGS:Nine trials...

journal_title：Current opinion in cardiology

authors： White HD

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of recent clinical trial findings relevant to cardiovascular risk management in patients with diabetes. RECENT FINDINGS:Recent trial evidence has demonstrated benefits of routine blood pressure (BP) lowering, regardless of initial BP levels, in people with type 2 diabetes. In a...

journal_title：Current opinion in cardiology

authors： Patel A,Joshi R,de Galan B

更新日期：2009-07-01 00:00:00